ADVANCED SPACE CRUSADE recreates small-units action during the Imperial war against the Tyranids' Hive Fleet Kraken. One players moves squads of Space Marine Scouts inside the guts of a Hiveship, and the other defends the bioship by placing "blips" and Tyranid warriors and creations.

The game rules are very simple: Space marines move and fire, then Alien moves and fires. The map is built by the Tyranid player according to a secret map he prepares before. The space marines explore and attack, hoping to survive the waves of aliens. The models have different actions and options during the game.